Christina Applegate reunited with her Married… With Children castmates Ed O’Neill, Katey Sagal, and David Faustino on January 28 at Los Angeles’ historic Wiltern Theatre for a live onstage event benefiting Race to Erase MS, the multiple sclerosis research charity Applegate has publicly supported since her own 2021 diagnosis.

The Wiltern Theatre in Los Angeles hosted the January reunion. Photo: Caroline Hernandez / Unsplash.

Key Points

• The event, billed “An Evening with the Bundys: The Married… With Children Cast Reunion,” reunited all four core Bundy-family actors for the first time in years, per Parade’s reporting.
• Tickets went on sale October 30, 2025 at 10 a.m. PT through Ticketmaster, with $2 from every ticket sold directed to Race to Erase MS, according to IMDb’s coverage of the announcement.
• Race to Erase MS was founded in 1993 by Nancy Davis and has raised more than $56 million for multiple sclerosis research through its Center Without Walls program, per Parade.
• Applegate, who revealed her MS diagnosis in 2021, has spoken candidly on her own podcast about living with the disease, once describing herself as “trapped in, like, this darkness right now that I haven’t felt in, like, I don’t even know how long, probably 20-something years.”

Married… With Children was appointment viewing throughout its 11-season run on Fox. Photo: Lucrezia Carnelos / Unsplash.

Why It Matters

Married… With Children ran for 11 seasons on Fox, from 1987 to 1997, and made Applegate, O’Neill, Sagal, and Faustino household names as the dysfunctional Bundy family. A full-cast reunion of that scale is rare on its own, but this one carried extra weight given Applegate’s health: she has largely stepped back from high-profile public appearances since her diagnosis, making the Wiltern event one of her more visible outings with former castmates in recent memory. Directing ticket proceeds to Race to Erase MS turned what could have been a straightforward nostalgia cash-grab into something with a direct line back to Applegate’s own circumstances.

The reunion adds to a run of high-profile sitcom cast reunions in recent years, but the charitable framing sets it apart from a typical convention panel or streaming-platform special. For fans who grew up on the show’s Sunday-night lineup, it’s also a reminder of how much time has passed: the series wrapped nearly three decades ago, and this was reportedly one of the first times all four leads have shared a stage together since.

Race to Erase MS has built its fundraising model around exactly this kind of star-driven event, pairing celebrity draw with a direct research pipeline through its Center Without Walls network of specialists. For Applegate specifically, appearing at a Bundy-family reunion doubles as both a nostalgia moment for longtime fans and a visible show of support for a cause tied directly to her own health, giving the event a rare mix of sitcom throwback and genuine advocacy.